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Can the art of predictive medicine anticipate the development of
diabetes? And if so, what can be done about it? How early is early
enough to intervene effectively? With what therapeutic modality?
Why? Big babies are not an infrequent occurrence in mothers with
normal carbohydrate metabolism for another 10, 20, or even 30
years. The abnor- mality present during pregnancy is now accepted
as what is inherited with the diabetic predisposition, or what can
be recognized as the diabetic susceptibility. It occurs before
hyperglycemia, during the phase of dy- namic resistance to
diabetes, during the prediabetic period. Prediabetes means before
diabetes, and was applied for the first time by Mara~on in Spain,
to signify the stage before hyperglycemia. Foglia in Argentina used
the term in 1944 for his pancreatectomized rats. We pub- lished the
first paper on humans in 1951 (Camerini-Davalos, R.A., Landabure,
P., and Serantes, N., Rev Med Cordoba 39: 187).
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